The Struggle with Rheumatism through Dracunculus vulgaris Schott: In the Light of Ethnobotanical Information

(E-pub Ahead of Print)

Author(s): Fatma Tuğçe Gürağaç Dereli, Mert Ilhan, Esra Küpeli Akkol*

Journal Name: Current Molecular Pharmacology

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Background: The fruits with the seeds of Dracunculus vulgaris Schott. (Araceae) are used against inflammatory diseases in Turkey.

Objective: Present study was designed to justify this folkloric usage type of the plant. Therefore, the aim of this study is to investigate the anti-inflammatory activity of D. vulgaris.

Methods: Petroleum ether, ethyl acetate and methanol extracts were prepared from the fruits, successively. Carrageenan-, serotonin-, and prostaglandin E2-induced hind paw edema; acetic acid–induced capillary permeability and 12-O-tetradecanoyl-phorbol-13-acetate–induced mouse ear edema models were used to assess the antiinflammatory activity of the extracts. The analgesic activity was experienced by using p-benzoquinone-induced abdominal constriction test.

Results: The petroleum ether extract displayed the highest activities in all of the used test models compared with the control group. Therefore, the constituents of this extract were determined by using gas chromatography–mass spectroscopy (GC–MS). Linoleic acid was found to be major constituent of the petroleum ether extract of D. vulgaris.

Conclusion: This study has provided some justification for the folkloric use of the plant.

Keywords: Analgesic, anti-inflammatory, araceae, dracunculus vulgaris, ethnopharmacology, rheumatism

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(E-pub Ahead of Print)
DOI: 10.2174/1874467213666200502020345
Price: $95

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