Background: The fruits with the seeds of Dracunculus vulgaris Schott. (Araceae) are used against
inflammatory diseases in Turkey.
Objective: Present study was designed to justify this folkloric usage type of the plant. Therefore, the aim of this study
is to investigate the anti-inflammatory activity of D. vulgaris.
Methods: Petroleum ether, ethyl acetate and methanol extracts were prepared from the fruits, successively.
Carrageenan-, serotonin-, and prostaglandin E2-induced hind paw edema; acetic acid–induced capillary permeability
and 12-O-tetradecanoyl-phorbol-13-acetate–induced mouse ear edema models were used to assess the antiinflammatory activity of the extracts. The analgesic activity was experienced by using p-benzoquinone-induced
abdominal constriction test.
Results: The petroleum ether extract displayed the highest activities in all of the used test models compared with the
control group. Therefore, the constituents of this extract were determined by using gas chromatography–mass
spectroscopy (GC–MS). Linoleic acid was found to be major constituent of the petroleum ether extract of D.
Conclusion: This study has provided some justification for the folkloric use of the plant.