Perspectives of Deregulated Metabolism in Breast Cancer
Pp. 178-207 (30)
Cancer cells devise different mechanisms to undergo aberrant cell division.
Dysregulated signaling pathways and metabolic reprogramming are the two key
mechanisms leading to cancer development. The role of metabolic dysregulation has
been well known in cell proliferation, metastasis, and resistance to therapy, eventually
leading to tumor progression. The dysregulation of enzyme activity and biochemical
pathways have emerged as major factors in the metabolic reprogramming of breast
cancer. The abnormal changes in the level of metabolites are mechanistically
associated with the metabolism of cancer. Quantitative research studies have provided
a list of metabolic biomarkers, which have a promising role in the early detection of
breast cancer as well as in its therapy. Many of the current research studies are directed
towards understanding the intricacies of metabolism in cancer cell proliferation. This
chapter gives an overview of breast cancer metabolism with updated information and
describes how deregulated metabolism plays a key role in the oncogenic cascade
leading to the neoplastic transformation of cells.
Amino acid, Cancer, Carbohydrate, Glycolytic pathways,
Immunometabolism, Lipid, Metabolism, TCA cycle.