Title:Current and Future of Alzheimer's Therapy with the Best Approach
VOLUME: 19 ISSUE: 9
Author(s):Harminder Singh, Viney Chawla*, Ritu Bala and Harish Dureja
Affiliation:Department of Pharmacology, GGS Medical College, Faridkot, Punjab, Department of Pharmaceutics, University Institute of Pharmaceutical Sciences and Research, Baba Farid University of Health Sciences, Faridkot, Punjab, Department of Pharmacology, GGS Medical College, Faridkot, Punjab, Division of Pharmaceutics, Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana
Keywords:Alzheimer’s disease, neuro-inflammation, immunoglobulins, monoclonal antibodies, peripheral metabolic deregulation,
immunotherapy
Abstract:Introduction: In spite of the steady progress in the understanding of the etiopathogenesis of
Alzheimer's Disease (AD) for the last 50 years, exceptionally few long-standing drugs are, at present,
used for AD therapy. New interventions that either prevent, slow or stop the disease are urgently warranted
to overcome the growing AD burden. The aim of this narrative review is to summarize the currently
existing preclinical and clinical evidence regarding new drug development and biomarkers for
better understanding and focused management of AD. This article reviews the various potential and
existing targets /receptors with valid biomarkers applied in recent years to address the early-stage tasks
of the AD drug discovery process. A comprehensive literature search was conducted in the relevant
databases to identify studies published in recent years. In conclusion, the new approaches seem to aim
at examining the prospective neuroprotective activity of disease-modifying drugs in the presymptomatic
phases of AD, using biomarkers that detect progression of the disease before the growth of overt
dementia.
