Nature always remains an inexhaustible source of treasures for mankind. It remains a mystery for every
challenge until the completion of the challenge. While we talk about the complicated health issues, nature
offers us a great variety of chemical scaffolds and their various moieties packed in the form of natural
products e.g., plants, microorganisms (fungi, algae, protozoa), and terrestrial vertebrates and
invertebrates. This review article is an update about jaceosidin, a bioactive flavone, from genus Artemisia.
This potentially active compound exhibits a variety of pharmacological activities including antiinflammatory, anti-oxidant, anti-bacterial, anti-allergic and anti-cancer. The bioactivities and the
therapeutic action of jaceosidin, especially the modulation of different cell signaling pathways (ERK1/2,
NF-κB, PI3K/Akt and ATM-Chk1/2) which become deregulated in various pathological disorders, have
been focused here. The reported data suggest that the bioavailability of this anti-cancer compound should
be enhanced by utilizing various chemical biology and medicinal chemistry techniques. Moreover, it is
recommended that researchers and scientists should work on the mode of action of this particular flavone
to precede it further as a potent anti-cancer compound.