Inflammatory bowel disease (IBD) is an immune-mediated chronic inflammatory disease.
Although the etiology is uncertain, there is marked disbalance of mucosal immune responses in part
shaped by genetic susceptibility and intestinal microbial dysbiosis. Suppressing inflammatory activity
adequately and maintaining this suppression are the main goals of current therapies. However, corticosteroids
are only suitable for therapy of active disease, and the effects of immunosuppressive agents
are mainly limited to maintenance of remission. Biologics have become widely available and provide
therapeutic benefits to IBD patients. However, only a part of patients benefits from them. Thus, there
is an urgent need for the development of new substances in the therapy of IBD. Exosomes are nanosized
lipid vesicles identified recently. They are secreted from all living cells and then distributed in
various human body fluids. The components, such as microRNAs and functional proteins, secreted by
exosomes in different cells have been reported to be involved in the pathogenesis of IBD. Therefore,
exosomes have the potential to become appealing particles in treating IBD as a cell-free therapeutic
approach as well as biomarkers for diagnosis and monitoring disease status. Further studies are needed
to investigate the practicality, safety and desirable effects of exosomes in clinical applications in IBD.
Keywords: Exosomes, inflammatory bowel disease, pathogenesis, cell-free therapy, clinical application, microRNAs.
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