Background: Monoamine oxidases (MAOs) play a crucial role during the development of
various neurodegenerative disorders. There are two MAO isozymes, MAO-A and MAO-B. MAO-A is
a flavoenzyme, which binds to the outer mitochondrial membrane and catalyzes the oxidative
transformations of neurotransmitters like serotonin, norepinephrine, and dopamine.
Materials and Methods: Focus on synthetic studies has culminated in the preparation of many MAOA
inhibitors, and advancements in combinatorial and parallel synthesis have accelerated the
developments of synthetic schemes. Here, we provided an overview of the synthetic protocols
employed to prepare different classes of MAO-A inhibitors. We classified these inhibitors according to
their molecular scaffolds and the synthetic methods used.
Results: Various synthetic and natural derivatives from a different class of MAO-A inhibitors were reported.
Conclusion: The review provides a valuable tool for the development of a new class of various
selective MAO-A inhibitors for the treatment of depression and other anxiety disorders.