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Current Drug Delivery

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ISSN (Print): 1567-2018
ISSN (Online): 1875-5704

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Physicochemical Considerations of Tumor Selective Drug Delivery and Activity Confinement with Particular Reference to 1,2-Bis(Sulfonyl)-1- Alkylhydrazines Delivery

Author(s): Philip Penketh*, Hugh Williamson and Krishnamurthy Shyam

Volume 17, Issue 5, 2020

Page: [362 - 374] Pages: 13

DOI: 10.2174/1567201817666200427215044

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Abstract

Hypoxic tumor cell sub-populations are highly resistant to radiotherapy and their presence frequently causes disease recurrence and death. Here, we described the physicochemical properties required to develop superior tumor-targeted hypoxia-activated modular prodrugs that liberate extremely short-lived bis(sulfonyl)hydrazines (BSHs) as reactive cytotoxins, thereby precisely focusing cytotoxic stress on these radio-resistant hypoxic sub-populations. Therefore, cytotoxic stress will be focused on radiation resistant areas and thus strongly synergizing with radiotherapy.

Keywords: Hypoxic tumor cell, bis(sulfonyl)hydrazines (BSHs), cytotoxic stress, hypoxic sub-populations, radiotherapy, hypoxic sub-populations.

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