A Concise Review on Multidimensional Silver Nanoparticle Health Aids and Threats

Author(s): Parmita Phaugat, Aparna Khansili*, Suchitra Nishal, Beena Kumari

Journal Name: Current Drug Therapy

Volume 15 , Issue 5 , 2020


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Graphical Abstract:


Abstract:

Nanoparticles (Np) are the 21st century material in supreme formulations due to their unique properties and design. In review, systematic discussion of the synthesis, characterization, bio-applications, and risks of AgNps (Silver Nanoparticles) especially highlighting anticancer activity envisaging mechanisms as well as therapeutic approaches for cancer. Ag-Nps mainly possess toxicological concern.

Benefits and Risk: AgNps have beneficial approaches for cancer treatment and angiogenesisrelated diseases like rheumatoid arthritis, atherosclerosis, diabetic psoriasis, retinopathy, endometriosis, and adiposity.

Ag-Nps induced cytotoxicity through oxidative stress by the ROS (Reactive Oxygen Species) generation could be measured as dependent on different properties, such as nanoparticle shape, size, agglomeration, concentration, and aggregation.

Results: The advancing nanotechnology-based therapy needs to be devised better, and it should offload the hitches of prevailing treatment approaches. Essential studies are required to explain the synergistic effect of two different cytotoxic agents.

Keywords: AgNp, physicochemical properties, synthesis, ROS, cytotoxicity, antimicrobial action, risks, and benefits.

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Article Details

VOLUME: 15
ISSUE: 5
Year: 2020
Published on: 25 April, 2020
Page: [457 - 468]
Pages: 12
DOI: 10.2174/1574885515999200425234517
Price: $65

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