A Concise Review on Multidimensional Silver Nanoparticle Health Aids and Threats

(E-pub Ahead of Print)

Author(s): Parmita Phaugat, Aparana Khansili*, Suchitra Nishal, Beena Kumari

Journal Name: Current Drug Therapy

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Abstract:

Nanoparticles (Np) are the 21st century material in supreme formulations due to their unique properties and design. In review, systematic discussion of the synthesis, characterization, bio-applications and risks of AgNps (Silver Nanoparticles) specially highlighting anticancer activity envisaging mechanisms as well as therapeutic approaches for cancer. Ag-Nps mainly possess toxicological concern.

Benefits and Risk: AgNps have beneficial approaches for cancer treatment and angiogenesis-related diseases like rheumatoid arthritis, atherosclerosis, diabetic psoriasis, retinopathy, endometriosis and adiposity. Ag-Nps induced cytotoxicity through oxidative stress by the ROS (Reactive Oxygen Species) generation could be measured as dependent on different properties such as nanoparticle shape, size, agglomeration, concentration and aggregation.

Result: The advancing nanotechnology-based therapy need to be devised better, and it should offload the hitches of prevailing treatment approaches. Essential studies are required to explain the synergistic effect of two different cytotoxic agents.

Keywords: AgNp, Physicochemical properties, Synthesis, ROS, Cytotoxicity, Antimicrobial action, Risks and Benefits.

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1574885515999200425234517
Price: $95

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