Interleukin-19 as an Immunoregulatory Cytokine

Author(s): Yasuyuki Fujimoto, Nobuyuki Kuramoto, Masanori Yoneyama, Yasu-Taka Azuma*

Journal Name: Current Molecular Pharmacology

Volume 14 , Issue 2 , 2021


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Abstract:

IL-19 is a type of anti-inflammatory cytokine. Since the receptor for IL-19 is common to IL-20 and IL-24, it is important to clarify the role of each of the three cytokines. If three different cytokines bind to the same receptor, these three may have been produced to complement the other two. However, perhaps it is unlikely. Recently, the existence of a novel receptor for IL-19 was suggested. The distinction between the roles of the three cytokines still makes sense. On the other hand, because T cells do not produce IL-19, their role in acquired immunity is limited or indirect. It has been reported that IL-19 causes inflammation in some diseases but does not have an anti-inflammatory effect. In this review, we introduce the current role of IL-19 in each disease. In addition, we will describe the molecular mechanism of IL-19 and its development for the prevention of diseases. IL-19 was previously considered an anti-inflammatory cytokine, but we would like to propose it as an immunoregulatory cytokine.

Keywords: Interleukin 19, anti-inflammatory agents, mediators of inflammation, immunological disease, interleukin-20 receptors, drug targeting.

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Article Details

VOLUME: 14
ISSUE: 2
Year: 2021
Published on: 31 December, 2020
Page: [191 - 199]
Pages: 9
DOI: 10.2174/1874467213666200424151528
Price: $65

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