Background: In this work, new heterocyclic compounds containing 3-(4-tertbutylphenyl)-
5-cyclopropyl-4H-1,2,4-triazole ring were synthesized, starting from iminoester hydrochlorides
Methods: Ethyl N-[(4-tert-butylphenyl)carbonyl]cyclopropanecarbohydrazonoate was used to synthesize
(arylmethylamino)-4H-1,2,4-triazole and their phthalonitrile derivatives sequentially.
Results: Seventeen new 3-(4-tert-butylphenyl)-5-cyclopropyl-4H-1,2,4-triazole derivatives were
synthesized and their antioxidant and antimicrobial activities were determined.
Conclusion: Imine and amine derivatives were better antioxidants than phthalonitrile derivatives.
Doubly fluorination compounds appeared to result in higher activity. The compounds tested with
five microorganisms showed better activity against B. subtilis with the antimicrobial activity of two
far exceeding that of ampicillin. Imine and amine derivatives were better antimicrobials than phthalonitrile