Title:Albumin-based Nanoparticles as Promising Drug Delivery Systems for Cancer Treatment
VOLUME: 17 ISSUE: 3
Author(s):Ozge Esim and Canan Hascicek*
Affiliation:Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, Ankara, Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, Ankara
Keywords:Albumin, cancer treatment, characterization of nanoparticles, drug delivery systems, drug release, nanoparticle.
Abstract:Albumin is an ideal material for the production of drug carrier nanoparticular systems since
it is a versatile and functional protein that has been proven to be biodegradable and biocompatible,
non-toxic, and immunogenic. Albumin nanoparticles are of great interest as they have the high binding
capacity to many drugs with different physicochemical and structural properties and are well tolerated
without any side effects. In this review, different types of albumin, special nanotechnological techniques
for the production of albumin nanoparticles, such as desolvation, emulsification, thermal gelation,
nano-spray drying, and self-assembly, as well as the characterization of albumin nanoparticles,
such as particle size, surface charge, morphological properties, drug content, and release profile have
been discussed. In addition, the in vitro and in vivo studies of albumin nanoparticles intended both diagnostic
and therapeutic usage have been investigated.
