Bioactive Compounds in Diabetic Cardiomyopathy: Current Approaches and Potential Diagnostic and Therapeutic Targets

(E-pub Ahead of Print)

Author(s): Sandeep Kumar Kotturu, V. V. Sathibabu Uddandrao, Sudip Gosh, Brahmanaidu Parim*

Journal Name: Cardiovascular & Hematological Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents)

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Abstract:

Diabetic cardiomyopathy (DCM) as an imperative menace to health takes place without or with coexistence of vascular diseases. Even though numerous pathological mechanisms are accountable for DCM have been estimated, oxidative stress is extensively well thought-out as a foremost key cause for the pathogenesis of the DCM. In this review we focused on role of bioactive compounds using different sources like plant and marine products in cardiomyopathy. Natural products and their related constituents have traditionally been implausible as a resource of curative agents. In last few decades, studies into natural products in the pharma field has condensed, still to pay to problems such as the requirement of compatibility of conventional natural product extract libraries with high‒throughput selection. From ancient time documented that natural product structures have the characteristics of high chemical variety, biochemical specificity and other molecular properties that make them favorable as direct structures for drug invention, and which provide to distinguish them from libraries of combinatorial and synthetic compounds. Consequently, the aim of this review is to provide an overview on the recent progress and development in the bio-active compounds in DCM and also to focus on the cellular mechanisms underlying cardiomyocyte dysfunction for their therapeutic targets.

Keywords: Diabetic cardiomyopathy, hyperglycemia, insulin pathway, endothelial dysfunction, plant products, bioactive compounds.

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(E-pub Ahead of Print)
DOI: 10.2174/1871525718666200421114801
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