Oleanolic Acid Derived from Plants: Synthesis and Pharmacological Properties of A-ring Modified Derivatives

Author(s): Tingjuan Wu, Xu Yao, Guan Wang, Xiaohe Liu, Hongfei Chen, Zehua Yang, Xing Zheng*

Journal Name: Letters in Drug Design & Discovery

Volume 17 , Issue 9 , 2020

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Abstract:

Background: Oleanolic Acid (OA) is a ubiquitous product of triterpenoid compounds. Due to its inexpensive availability, unique bioactivities, pharmacological effects and non-toxic properties, OA has attracted tremendous interest in the field of drug design and synthesis. Furthermore, many OA derivatives have been developed for ameliorating the poor water solubility and bioavailability.

Objective: Over the past few decades, various modifications of the OA framework structure have led to the observation of enhancement in bioactivity. Herein, we focused on the synthesis and medicinal performance of OA derivatives modified on A-ring. Moreover, we clarified the relationship between structures and activities of OA derivatives with different functional groups in A-ring. The future application of OA in the field of drug design and development also was discussed and inferred.

Conclusion: This review concluded the novel achievements that could add paramount information to the further study of OA-based drugs.

Keywords: Oleanolic acid derivatives, A-ring modified, pharmacological properties, synthesis, triterpenoid compounds, triterpenes.

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Article Details

VOLUME: 17
ISSUE: 9
Year: 2020
Page: [1084 - 1101]
Pages: 18
DOI: 10.2174/1570180817999200420115456
Price: $65

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