The liver represents the major site of drug metabolism, i.e. the key organ in the processes of detoxification
and elimination of drugs from the organism. It is therefore often affected by toxic metabolites and suffers sometimes
fatal consequences. The spectrum of pathologies differs by the cell type primarily damaged and the group of the
cholangiopathies includes those conditions affecting the bile duct epithelium or the cholangiocytes. They can range
from transient cholestasis to vanishing bile duct syndrome and sclerosing cholangitis, both leading eventually to the
development of biliary fibrosis and cirrhosis.
In this review article, we focus on the etiology, predisposing factors, clinical manifestations, and histopathological
characteristics of bile duct injury as a consequence of drug treatment and discuss separately the different bile duct
Keywords: Drug-induced bile duct injury, histopathology, bile duct, cholangiocyte, cholestasis, vanishing bile duct syndrome (VBDS).
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