Drug-induced Bile Duct Injury - A Short Review

Author(s): Inna Dobreva*, Petko Karagyozov.

Journal Name: Current Drug Metabolism

Volume 21 , Issue 4 , 2020

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Abstract:

The liver represents the major site of drug metabolism, i.e. the key organ in the processes of detoxification and elimination of drugs from the organism. It is therefore often affected by toxic metabolites and suffers sometimes fatal consequences. The spectrum of pathologies differs by the cell type primarily damaged and the group of the cholangiopathies includes those conditions affecting the bile duct epithelium or the cholangiocytes. They can range from transient cholestasis to vanishing bile duct syndrome and sclerosing cholangitis, both leading eventually to the development of biliary fibrosis and cirrhosis.

In this review article, we focus on the etiology, predisposing factors, clinical manifestations, and histopathological characteristics of bile duct injury as a consequence of drug treatment and discuss separately the different bile duct pathologies.

Keywords: Drug-induced bile duct injury, histopathology, bile duct, cholangiocyte, cholestasis, vanishing bile duct syndrome (VBDS).

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Article Details

VOLUME: 21
ISSUE: 4
Year: 2020
Page: [256 - 259]
Pages: 4
DOI: 10.2174/1389200221666200420100129
Price: $65

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