The Long-Term Effect of Medically Enhancing Melanin Intrinsic Bioenergetics Capacity in Prematurity

Author(s): Arturo S. Herrera, Paola E. Solís Arias, María del C.A. Esparza, Luis F.T. Bernal, Andrey D. Bondarev, Vladimir P. Fisenko, Vladimir N. Chubarev, Nina N. Minyaeva, Liudmila M. Mikhaleva, Vadim V. Tarasov, Siva G. Somasundaram, Cecil E. Kirkland, Gjumrakch Aliev*

Journal Name: Current Genomics

Volume 21 , Issue 7 , 2020


Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Abstract:

Background: The ability of the human body to produce metabolic energy from light modifies fundamental concepts of biochemistry.

Objective: This review discusses the relationships between the long-accepted concept is that glucose has a unique dual role as an energy source and as the main source of carbon chains that are precursors of all organic matter. The capability of melanin to produce energy challenges this premise.

Methods: The prevalent biochemical concept, therefore, needs to be adjusted to incorporate a newly discovered state of Nature based on melanin’s ability to dissociate water to produce energy and to reform water from molecular hydrogen and oxygen.

Results and Discussion: Our findings regarding the potential implication of QIAPI-1 as a melanin precursor that has bioenergetics capabilities.

Conclusion: Specifically, we reported its promising application as a means for treating retinopathy of prematurity (ROP). The instant report focuses on the long-term treatment medical effects of melanin in treating ROP.

Keywords: Melanin, energy, retina, oxygen, hydrogen, prematurity, retinopathy of prematurity.

[1]
Zhang, W.; Ito, Y.; Berlin, E.; Roberts, R.; Berkowitz, B.A. Role of hypoxia during normal retinal vessel development and in experimental retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci., 2003, 44(7), 3119-3123.
[http://dx.doi.org/10.1167/iovs.02-1122] [PMID: 12824260]
[2]
Staniforth, A.D.; Kinnear, W.J.M.; Starling, R.; Cowley, A.J. Nocturnal desaturation in patients with stable heart failure. Heart, 1998, 79(4), 394-399.
[http://dx.doi.org/10.1136/hrt.79.4.394] [PMID: 9616350]
[3]
Tasker, C.; Crosby, J.H.; Stradling, J.R. Evidence for persistence of upper airway narrowing during sleep, 12 years after adenotonsillectomy. Arch. Dis. Child., 2002, 86(1), 34-37.
[http://dx.doi.org/10.1136/adc.86.1.34] [PMID: 11806880]
[4]
Ortiz, F.O.; Aldrich, T.K.; Nagel, R.L.; Benjamin, L.J. Accuracy of pulse oximetry in sickle cell disease. Am. J. Respir. Crit. Care Med., 1999, 159(2), 447-451.
[http://dx.doi.org/10.1164/ajrccm.159.2.9806108] [PMID: 9927356]
[5]
Linsenmeier, R.A. Electrophysiological consequences of retinal hypoxia. Graefes Arch. Clin. Exp. Ophthalmol., 1990, 228(2), 143-150.
[http://dx.doi.org/10.1007/BF00935724] [PMID: 2338252]
[6]
Fielder, A.R. There’s more to ROP than ROP. J. AAPOS, 2013, 17(2), 121-123.
[http://dx.doi.org/10.1016/j.jaapos.2013.03.009] [PMID: 23622443]
[7]
Quinn, G.E.; Dobson, V.; Kivlin, J.; Kaufman, L.M.; Repka, M.X.; Reynolds, J.D.; Gordon, R.A.; Hardy, R.J.; Tung, B.; Stone, R.A. Cryotherapy for retinopathy of prematurity cooperative group. Prevalence of myopia between 3 months and 5 1/2 years in preterm infants with and without retinopathy of prematurity. Ophthalmology, 1998, 105(7), 1292-1300.
[http://dx.doi.org/10.1016/S0161-6420(98)97036-1] [PMID: 9663236]
[8]
Fouzdar Jain, S.; Song, H.H.; Al-Holou, S.N.; Morgan, L.A.; Suh, D.W. Retinopathy of prematurity: preferred practice patterns among pediatric ophthalmologists. Clin. Ophthalmol., 2018, 12, 1003-1009.
[http://dx.doi.org/10.2147/OPTH.S161504] [PMID: 29881255]
[9]
Holmström, G.; Tornqvist, K.; Al-Hawasi, A.; Nilsson, Å.; Wallin, A.; Hellström, A. Increased frequency of retinopathy of prematurity over the last decade and significant regional differences. Acta Ophthalmol., 2018, 96(2), 142-148.
[http://dx.doi.org/10.1111/aos.13549] [PMID: 29068172]
[10]
Blencowe, H.; Moxon, S.; Gilbert, C. Update on blindness due to retinopathy of prematurity globally and in India. Indian Pediatr., 2016, 53(Suppl. 2), S89-S92.
[PMID: 27915313]
[11]
Avery, M.E. Recent increase in mortality from hyaline membrane disease. J. Pediatr., 1960, 57, 553-559.
[http://dx.doi.org/10.1016/S0022-3476(60)80083-2] [PMID: 13685272]
[12]
McDonald, A.D. Oxygen treatment of premature babies and cerebral palsy. Dev. Med. Child Neurol., 1964, 6, 313-314.
[http://dx.doi.org/10.1111/j.1469-8749.1964.tb10800.x] [PMID: 14155197]
[13]
BOOST-II. Australia. Outcomes of two trials of oxygen-saturation targets in preterm infants. N. Engl. J. Med., 2016, 374(8), 749-760.
[http://dx.doi.org/10.1056/NEJMoa1514212] [PMID: 26863265]
[14]
Philip, A.G.S. The evolution of neonatology. Pediatr. Res., 2005, 58(4), 799-815.
[http://dx.doi.org/10.1203/01.PDR.0000151693.46655.66] [PMID: 15718376]
[15]
Berkowitz, B.A.; Zhang, W. Significant reduction of the panretinal oxygenation response after 28% supplemental oxygen recovery in experimental ROP. Invest. Ophthalmol. Vis. Sci., 2000, 41(7), 1925-1931.
[PMID: 10845618]
[16]
Herrera, A.S.; Solis Arias, M.P. The odyssey of atmospheric oxygen in their futile attempt to reach the interior of the cell. Intl. J. Health Res. Innov., 2013, 1, 37-52.
[17]
Herrera, A.S.; Arias Esparza, M.D.C.; Arias, P.E.S.; Ashraf, G.M.; Mosa, O.F.; Fisenko, V.P.; Sologova, S.S.; Dostdar, S.A.; Sokolov, A.V.; Bovina, E.V.; Chubarev, V.N.; Tarasov, V.V.; Somasundaram, S.G.; Kirkland, C.E.; Aliev, G. The role of melanin to dissociate oxygen from water to treat retinopathy of prematurity. Cent. Nerv. Syst. Agents Med. Chem., 2019, 19, 1-8.
[http://dx.doi.org/10.2174/1871524919666190702164206] [PMID: 31267880]
[18]
Herrera, A.S.; Del, C.A.; Esparza, M.; Md Ashraf, G.; Zamyatnin, A.A.; Aliev, G. Beyond mitochondria, what would be the energy source of the cell? Cent. Nerv. Syst. Agents Med. Chem., 2015, 15(1), 32-41.
[http://dx.doi.org/10.2174/1871524915666150203093656] [PMID: 25645910]
[19]
Herrera, A.S.; Ashraf, G.M.; Del Carmen, A.E.M.; Tarasov, V.V.; Chubarev, V.N.; Avila-Rodriguez, M.F.; Makhmutova, A.; Ganash, M.; Mosa, O.F.; Hafeez, A.; Bachurin, S.O.; Aliev, G. Cerebrospinal fluid, brain electrolytes balance, and the unsuspected intrinsic property of melanin to dissociate the water Molecule. CNS Neurol. Disord. Drug Targets, 2018, 17(10), 743-756.
[http://dx.doi.org/10.2174/1871527317666180904093430] [PMID: 30179148]
[20]
Solís-Herrera, A.; Ashraf, G.M. del C A Esparza, M.; Arias, R.I.; Bachurin, S.O.; Barreto, G.E.; Aliev, G. Biological activities of QIAPI 1 as a melanin precursor and its therapeutic effects in wistar rats exposed to arsenic poisoning. Cent. Nerv. Syst. Agents Med. Chem., 2015, 15(2), 99-108.
[http://dx.doi.org/10.2174/1871524915666150424113831] [PMID: 25909193]


Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 21
ISSUE: 7
Year: 2020
Page: [525 - 530]
Pages: 6
DOI: 10.2174/1389202921999200417172817
Price: $65

Article Metrics

PDF: 22
HTML: 2
EPUB: 1
PRC: 1