Title:Lipid Nanoparticles as a Skin Wound Healing Drug Delivery System: Discoveries and Advances
VOLUME: 26 ISSUE: 36
Author(s):Myla Lôbo de Souza, Widson Michael dos Santos, André Luiz Moreira Domingues de Sousa, Victor de Albuquerque Wanderley Sales, Fernanda Pontes Nóbrega, Marcos Victor Gregorio de Oliveira and Pedro José Rolim-Neto*
Affiliation:Laboratory of Drug Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Pernambuco, Laboratory of Drug Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Pernambuco, Laboratory of Drug Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Pernambuco, Laboratory of Drug Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Pernambuco, Laboratory of Drug Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Pernambuco, Laboratory of Drug Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Pernambuco, Laboratory of Drug Technology, Department of Pharmaceutical Sciences, Federal University of Pernambuco, Recife, Pernambuco
Keywords:Nanocarriers, lipid nanoparticles, cicatrization, wound healing, topical use, skin penetration.
Abstract:Chronic wounds are a remarkable cause of morbidity, requiring long-time treatments with a significant
impact on the quality of life and high costs for public health. Although there are a variety of topical skin preparations
commercially available, they have several limitations that frequently impair wound healing, such as drug
instability, toxicity, limited time of action and ineffective skin permeation. In recent years, researchers have focused
on the development of new effective treatments for wound healing and shown frequent interest in nanometric
drug delivery systems to overcome such obstacles. In dermatology, lipid nanoparticles (LNPs) have received
great attention from researchers due to their great functionalities, greater adhesion to the skin and film formation,
enabling the hydration and maintenance of skin integrity, as well as present a more effective penetration through
the skin barrier. This review provides an update on topical formulations based on Solid Lipid Nanoparticles
(SLNs) and Nanostructured Lipid Carriers (NLCs) as wound healing treatments. Both SLNs and NLCs are able to
increase solubility and stability of active pharmaceutical ingredients and increase skin penetration compared to
the free drugs. Additionally, SLNs and NLCs can increase pharmacological activity, increase the release profile
of the drugs, promote synergistic effects and improve the sensory properties of the final formulation. Topical
dosage forms containing nanoparticles have been extensively evaluated for wound healing activity, mainly the
dressings, films and scaffolds. Therefore, lipid nanoparticles have contributed in improving wound healing therapies
when incorporated into other dosage forms with better efficacy and lesser adverse effects than conventional
formulations.
