Pathogenic Mechanisms of a Stroke-like attack Elicited by Epidural Steroid Injection Therapy

Author(s): Zhen He*

Journal Name: Current Neurovascular Research

Volume 17 , Issue 3 , 2020


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Abstract:

Background: The pathogenic mechanisms involved in a disastrous scenario, following epidural steroid injections (ESI), remain unclarified. Intra-arterial injection of steroids with needlepenetrating vascular injury would be the culprit, as particulate medicine elicits a brain or spinal cord stroke-like attack.

Methods: On the other hand, the limited experimental approaches simulating an accidental steroid intra-arterial injection for ESI conflicted in their results: hemorrhage vs. ischemia.

Results: This article dissects the potential pathogenic mechanisms at a neurovascular unit. Noticeably, a schematic representation provides an explanation of how emboli formed by particulate steroids elicit either hemorrhagic, or ischemic lesion.

Conclusion: In addition, the development of a rat model with intravertebral artery steroid injection is a proposal to address the unmet need in evaluating steroids and vascular injury in ESI.

Keywords: Epidural steroid injections, stroke, living neurovascular unit, pathogenic mechanism, particulate steroids, spinal cord.

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Article Details

VOLUME: 17
ISSUE: 3
Year: 2020
Published on: 15 April, 2020
Page: [312 - 318]
Pages: 7
DOI: 10.2174/1567202617666200415143201
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