Background: Imidazo[1,2-a]pyrimidinone, quinazolinone and amide derivatives have attracted a lot
of interest because of their broad scope of biological and pharmacological activities. There are a lot of methods
reported in the literature for their synthesis. Therefore, we became interested in developing a convenient
synthetic method for the preparation of imidazoquinazolinone and amide derivatives.
Objective: NiFe2O4@SiO2 @glucose amine were synthesized, characterized and have been used for the green,
effective and mild multicomponent synthesis of quinazolinones, benzoimidazo[1,2-a]pyrimidinones and
amides under solvent-free conditions in short reaction times and excellent yields. To expand of the scope of
this avenue, multicomponent synthesis of mono and bis novel amides was tested for the first time. All of the
products were characterized by mp, FT-IR, NMR and elemental analysis.
Methods: Aldehyde (1mmol), 2-amino benzimidazole (1 mmol), dimedone (1mmol) or indane-1,3-dione (1
mmol) for the synthesis of quinazoline or imidazopyrimidinones and arene (1mmol), anhydride (1mmol), 2-
aminobenzimidazole (1mmol) for the synthesis of amides in the nanocatalyst NiFe2O4@SiO2@glucose amine
(0.15mol%: 0.05g) were stirred by a magnet for the required reaction time. After completion of the reaction, as
indicated by TLC, the products were collected and recrystallized from ethanol if necessary.
Results: We present a novel avenue for the synthesis of benzimidazo[1,2-a] pyrimidinones, quinazolinones and
amides in the presence of NiFe2O4@SiO2@glucose amine under solvent-free conditions.
Conclusion: In conclusion, we developed NiFe2O4@SiO2 @glucose amine-catalysed multicomponent
synthesis of quinazolinones and imidazo[1,2-a]pyrimidinones using the reaction of benzaldehyde, dimedone or
indane-dione and 2-aminobenzimidazole and multicomponent synthesis of amides using arenes, cyclic
anhydrides and 2-aminobenzimidazole by a solvent-free technique. This method proves to be a robust and
innovative approach for the synthesis of a biologically important structure. The operational simplicity, the
excellent yields of products, ease of separation and recyclability of the magnetic catalyst, waste reduction and
high selectivity are the main advantages of this method. Furthermore, this new avenue is cheap and