Extracts of Carolina jasmine (Gelsemium sempervirens (L.) J.St.-Hil.) petals were evaluated
in vitro for inhibition activity against protein tyrosine phosphatase 1B (PTP1B). The principle active
agent was also isolated from the extract and identified as ursolic acid (1). This is the first report of
ursolic acid from G. sempervirens and of PTP1B-inhibiting activity in the genus Gelsemium.
Keywords: Protein tyrosine phosphatase 1B inhibitor, Carolina jasmine, Gelsemium sempervirens, ursolic acid, petal, Gelsemiaceae.
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