Isolation and Identification of a Potent PTP1B Inhibitor, Ursolic Acid, from Carolina Jasmine (Gelsemium sempervirens (L.) J.St.-Hil.)

Author(s): Toshiro Noshita*, Yusuke Kakizoe, Satoshi Tanabe, Hidekazu Ouchi, Akihiro Tai

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 12 , 2020


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Abstract:

Extracts of Carolina jasmine (Gelsemium sempervirens (L.) J.St.-Hil.) petals were evaluated in vitro for inhibition activity against protein tyrosine phosphatase 1B (PTP1B). The principle active agent was also isolated from the extract and identified as ursolic acid (1). This is the first report of ursolic acid from G. sempervirens and of PTP1B-inhibiting activity in the genus Gelsemium.

Keywords: Protein tyrosine phosphatase 1B inhibitor, Carolina jasmine, Gelsemium sempervirens, ursolic acid, petal, Gelsemiaceae.

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Article Details

VOLUME: 17
ISSUE: 12
Year: 2020
Published on: 08 December, 2020
Page: [939 - 943]
Pages: 5
DOI: 10.2174/1570178617666200409101248
Price: $65

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