Background: Inflammation is a complex response of the host defense system to different internal and
external stimuli. It is believed that persistent inflammation may lead to chronic inflammatory diseases such as,
inflammatory bowel disease, neurological and cardiovascular diseases. Oxidative stress is the main factor responsible
for the augmentation of inflammation via various molecular pathways. Therefore, alleviating oxidative
stress is effective a therapeutic option against chronic inflammatory diseases.
Methods: This review article extends the knowledge of the regulatory mechanisms of flavonoids targeting inflammatory
pathways in chronic diseases, which would be the best approach for the development of suitable
therapeutic agents against chronic diseases.
Results: Since the inflammatory response is initiated by numerous signaling molecules like NF-κB, MAPK, and
Arachidonic acid pathways, their encountering function can be evaluated with the activation of Nrf2 pathway, a
promising approach to inhibit/prevent chronic inflammatory diseases by flavonoids. Over the last few decades,
flavonoids drew much attention as a potent alternative therapeutic agent. Recent clinical evidence has shown
significant impacts of flavonoids on chronic diseases in different in-vivo and in-vitro models.
Conclusion: Flavonoid compounds can interact with chronic inflammatory diseases at the cellular level and
modulate the response of protein pathways. A promising approach is needed to overlook suitable alternative compounds
providing more therapeutic efficacy and exerting fewer side effects than commercially available antiinflammatory