Background: Heavy metals are elements that are naturally found in the earth. They are used in many
modern-day applications in agriculture, medicine, and industry. Heavy metal poisoning occurs when the body’s
soft tissues absorb too much of a particular metal. The heavy metals of interest for this review paper were cadmium,
arsenic, mercury, and lead since these are the most common metals that the human body can absorb in
toxic amounts. Different plant species were investigated in recent years for their effect on oxidative stress parameters
after intoxication with heavy metals.
Objectives: This review paper is focused on the current update to research on heavy metals induced oxidative
stress in animal models and improvement of the oxidative stress parameters upon/co-/after treatment with different
plant extracts and isolated compounds.
Methods: The available literature was screened for the novel data regarding the influence of plant extracts and
compounds on heavy metals induced oxidative stress. For that purposes Scopus database was used, looking for
the publications in the last 5-10 years with the key terms: plant extracts, oxidative stress, in vivo, cadmium, lead,
mercury and arcenic.
Results: Various parameters of oxidative stress were investigated, and their improvement with plant extracts/
compounds was observed in the brain, lungs, kidneys, liver, uterus, testis, thymus, spleen, heart, skin and
blood of experimental animals. Common parameters used to determine oxidative stress in animals were: superoxide
dismutase; catalase; reduced glutathione; glutathione reductase; glutathione-S-transferase; glutathione peroxidase;
lipid peroxidation; oxidized glutathione; malondialdehyde; xanthine oxidase; nonprotein-soluble thiol;
thioredoxin reductase; total sulphydryl group; nitric oxide; γ-glutamyl cysteine synthetase.
Conclusion: The most investigated species for antioxidant effects upon intoxication with heavy metals seem to be
Allium sp., Bacopa monniera, Camellia sinensis, Moringa oleifera, Vitis vinifera and Zingiber officinale. According
to literature data, the most promising effect to alleviate symptoms of intoxication was achieved with proanthocyanidins
obtained from Vitis vinifera.