TRPC3-Based Protein Signaling Complex as a Therapeutic Target of Myocardial Atrophy

Author(s): Kazuhiro Nishiyama, Tomohiro Tanaka, Akiyuki Nishimura, Motohiro Nishida*

Journal Name: Current Molecular Pharmacology

Volume 14 , Issue 2 , 2021


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Graphical Abstract:


Abstract:

Transient receptor potential (TRP) channels, especially canonical TRP channel subfamily members 3 (TRPC3) and 6 (TRPC6), have gained attention as a putative therapeutic target of heart failure. Moreover, TRPC3 and TRPC6 channels are physiologically important for maintaining cellular homeostasis. How TRPC3/C6 channels alter intracellular signaling from adaptation to maladaptation, has been discussed for many years. We have recently shown that the formation of a protein signal complex between TRPC3 and NADPH oxidase (Nox) 2 caused by environmental stresses (e.g., hypoxia, nutritional deficiency, and anti-cancer drug treatment) promotes Nox2-dependent reactive oxygen species production and cardiac stiffness, including myocardial atrophy and interstitial fibrosis, in rodents. In fact, pharmacological prevention of the TRPC3 -Nox2 protein complex can maintain cardiac flexibility in mice after anti-cancer drug treatment.

In this mini-review, we discuss the relationship between TRPC3/C6 channels and cardiovascular disease, and propose a new therapeutic strategy by focusing on pathology-specific protein–protein interactions.

Keywords: TRPC3, TRPC6, Nox2, oncocardiology, protein–protein interaction, drug repurposing.

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VOLUME: 14
ISSUE: 2
Year: 2021
Published on: 06 April, 2020
Page: [123 - 131]
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DOI: 10.2174/1874467213666200407090121
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