Background: An eco-friendly, operationally simple and efficient reaction is shown between various
2,6-bis-(substituted-benzylidene)-cyclohexanones and differently substituted hydrazine in the presence of acetic
Methods: The reaction between various 2,6-bis-(substituted-benzylidene)-cyclohexanones and differently
substituted hydrazine in the presence of acetic acid afforded 7-Benzylidene-substituted-phenyl-3,3a,4,5,6,7-
hexahydro-2H-indazole in 74 to 92 % yield in short reaction time using the grindstone technique.
Results and Discussion: The notable advantages of this method include mild synthetic conditions, weak acid
catalysis, and non-hazardous solvent which make this method environmentally safer.
Conclusion: In conclusion, we have developed an efficient, simple and eco-friendly method for the synthesis of
7-Benzylidene-substituted-phenyl-3,3a,4,5,6,7-hexahydro-2H-indazole by grinding technique. The notable
benefits of this method are waste minimization, no organic solvent required, simple procedure, easy work-up,
and clean reaction profile.