Formulation and Evaluation of a Novel Itraconazole-Clotrimazole Topical Emulgel for the Treatment of Sporotrichosis

Author(s): Letícia L. Noronha, Patricia G. Ferreira, Carolina G.S. Lima, Luana P. Borba-Santos, Sonia Rozental, Marcela de Moraes, Fernando C. da Silva, Vitor F. Ferreira*, Débora O. Futuro.

Journal Name: Current Pharmaceutical Design

Volume 26 , Issue 14 , 2020

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Abstract:

In recent years, the development of new pharmaceutical formulations for the treatment of sporotrichosis has become a relevant research field. In this work, we aimed to develop an emulgel containing itraconazole and clotrimazole to ensure therapeutic effectiveness against Sporothrix brasiliensis. The topical use of a formulation that combines both drugs represents an interesting option for the complementary treatment of sporotrichosis. The emulgel formulation was prepared and evaluated for its zeta potential, viscosity, in vitro antifungal activity and stability at different storage conditions. The results showed that the newly developed emulgel displayed promising physicochemical characteristics, as well as a good in vitro inhibitory activity against S. brasiliensis yeasts. The results obtained in this work suggest that the emulgel containing itraconazole and clotrimazole might highly be efficient and a complementary therapy to oral administration in the treatment of sporotrichosis.

Keywords: Emulgel, sporotrichosis, itraconazole, clotrimazole, topical drug delivery systems, viscosity.

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Article Details

VOLUME: 26
ISSUE: 14
Year: 2020
Page: [1566 - 1570]
Pages: 5
DOI: 10.2174/1381612826666200406081249
Price: $65

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