This review summarizes the synthetic methodologies used in the last 25 years for the synthesis of
chalcones, which are a class of flavonoids having a 1,3-diphenyl-2-propene-1-one backbone. These compounds
are considered a hot topic in the field of medicinal chemistry, due to their pharmacological activity and because
they are important precursors for the synthesis of heterocyclic compounds with therapeutic applications such as:
flavones, flavanones, isoxazolines, benzothiazepines, pyrimidines and pyrazolines derivatives.
Keywords: Chalcones, scaffold, medicinal chemistry, pharmacological activity, flavones, flavanones, isoxazolines, benzothiazepines, pyrimidines,
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