Purpose: Breast cancer is the most probable cancer among women. However, the available
treatment is based on targeting different stages of breast cancer viz., radiation therapy, hormonal
therapy, chemotherapy, and surgical interventions, which have some limitations. The available
chemotherapeutics are associated with problems like low solubility, low permeability, high first-pass
metabolism, and P-glycoprotein efflux. Hence, the aforementioned restrictions lead to ineffective
treatment. Multiple chemotherapeutics can also cause resistance in tumors. So, the purpose is to develop
an effective therapeutic regimen for the treatment of breast cancer by applying a nanomedicinal
Methods: This review has been conducted on a systematic search strategy, based on relevant literature
available on Pub Med, MedlinePlus, Google Scholar, and Sciencedirect up to November 2019
using keywords present in abstract and title of the review. As per our inclusion and exclusion criteria,
226 articles were screened. Among 226, a total of 40 articles were selected for this review.
Results: The significant findings with the currently available treatment is that the drug, besides its
distribution to the target-specific site, also distributes to healthy cells, which results in severe side
effects. Moreover, the drug is less bioavailable at the site of action; therefore, to overcome this, a
high dose is required, which again causes side effects and lower the benefits. Nanomedicinal approaches
give an alternative approach to avoid the associated problems of available chemotherapeutics
treatment of breast cancer.
Conclusion: The nanomedicinal strategies are useful over the conventional treatment of breast cancer
and deliver a target-specific drug-using different novel drug delivery approaches.