Background: Since the last few decades, the healthcare sector is facing the problem of
the development of multidrug-resistant (MDR-TB) and extensively drug-resistant tuberculosis
(XDR-TB) infections all over the world. Regardless of the current healthcare progress for the
treatment of mycobacterial infections, we are still unable to control addition of every year 9 million
new cases of tuberculosis (TB).
Objective: We had an objective to synthesize some novel hydrazones, which were further subjected
to characterization, Photoluminescence study, in vitro anti-mycobacterium testing and in silico
Methods: Some new hydrazone derivatives have been successfully prepared by the condensation
reaction in the present study. All the compounds were characterized by using FTIR, NMR, UV,
Fluorescence spectroscopic techniques.
Results: All our newly synthesized compounds showed strong electronic excitation at 292.6 –
319.0 nm and displayed more intense emissions in the 348 – 365 nm regions except compound 3i.
The newly synthesized hydrazones 3a, 3b, 3f and 3g were found to be the most active compounds
and showed MIC (Minimum inhibitory concentrations) values of 12.5 μg/mL.
Conclusion: In the realm of development of more potent, effective, safer and less toxic
antituberculosis agents; our current study would definitely help the medicinal chemists to develop
potent analogues containing hydrazine motifs in them.