Inflammatory Bowel Disease (IBD) is an umbrella term used to describe disorders that involve
Crohn’s disease (CD), ulcerative colitis (UC) and pouchitis. The disease occurrence is more prevalent in
the working group population which not only hampers the well being of an individual but also has negative
economical impact on society. The current drug regime used therapy is very costly owing to the
chronic nature of the disease leading to several side effects. The condition gets more aggravated due to
the lower concentration of drug at the desired site. Therefore, in the present scenario, a therapy is needed
which can maximize efficacy, adhere to quality of life, minimize toxicity and doses, be helpful in maintaining
and stimulating physical growth of mucosa with minimum disease complications. In this aspect,
nanotechnology intervention is one promising field as it can act as a carrier to reduce toxicity, doses and
frequency which in turn help in faster recovery. Moreover, nanomedicine and nanodiagnostic techniques
will further open a new window for treatment in understanding pathogenesis along with better diagnosis
which is poorly understood till now. Therefore the present review is more focused on recent advancements
in IBD in the application of nanotechnology.
Keywords: Gastrointestinal, Inflammatory bowel disease, Nanomedicine, RNAi, SCFA, Polymeric nano-materials.
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