Application of Polymeric Nano-Materials in Management of Inflammatory Bowel Disease

Author(s): Prasad Minakshi*, Rajesh Kumar, Mayukh Ghosh, Basanti Brar, Manju Barnela, Preeti Lakhani

Journal Name: Current Topics in Medicinal Chemistry

Volume 20 , Issue 11 , 2020

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Graphical Abstract:


Abstract:

Inflammatory Bowel Disease (IBD) is an umbrella term used to describe disorders that involve Crohn’s disease (CD), ulcerative colitis (UC) and pouchitis. The disease occurrence is more prevalent in the working group population which not only hampers the well being of an individual but also has negative economical impact on society. The current drug regime used therapy is very costly owing to the chronic nature of the disease leading to several side effects. The condition gets more aggravated due to the lower concentration of drug at the desired site. Therefore, in the present scenario, a therapy is needed which can maximize efficacy, adhere to quality of life, minimize toxicity and doses, be helpful in maintaining and stimulating physical growth of mucosa with minimum disease complications. In this aspect, nanotechnology intervention is one promising field as it can act as a carrier to reduce toxicity, doses and frequency which in turn help in faster recovery. Moreover, nanomedicine and nanodiagnostic techniques will further open a new window for treatment in understanding pathogenesis along with better diagnosis which is poorly understood till now. Therefore the present review is more focused on recent advancements in IBD in the application of nanotechnology.

Keywords: Gastrointestinal, Inflammatory bowel disease, Nanomedicine, RNAi, SCFA, Polymeric nano-materials.

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