A series of benzimidazolyl-1,3,4-oxadiazoles (7a-k) were synthesized and evaluated for in
vitro anticancer activity against HeLa, MCF7, A549, and HEK293 cell lines. The results indicate that
compounds 7b, 7j and 7k have shown excellent anticancer activity and while most of the compounds
were non toxic to normal HEK293 cell lines. Molecular docking results of the synthesized compounds
with the target Pin1 protein were also discussed.
Keywords: 5-Substituted benzimidazoles, benzimidazolyl oxadiazoles, MTT assay, anticancer activity, molecular docking
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