Design, Synthesis, Anticancer Activity and Molecular Docking Studies of 2,5-Disubstituted-1,3,4-Oxadiazoles Containing Benzimidazole Moiety

Author(s): Ramamurthy Katikireddy, Ramu Kakkerla*, M.P.S. Murali Krishna, Gandamalla Durgaiah, Y.N. Reddy

Journal Name: Letters in Organic Chemistry

Volume 17 , Issue 12 , 2020

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Graphical Abstract:


A series of benzimidazolyl-1,3,4-oxadiazoles (7a-k) were synthesized and evaluated for in vitro anticancer activity against HeLa, MCF7, A549, and HEK293 cell lines. The results indicate that compounds 7b, 7j and 7k have shown excellent anticancer activity and while most of the compounds were non toxic to normal HEK293 cell lines. Molecular docking results of the synthesized compounds with the target Pin1 protein were also discussed.

Keywords: 5-Substituted benzimidazoles, benzimidazolyl oxadiazoles, MTT assay, anticancer activity, molecular docking studies.

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Article Details

Year: 2020
Published on: 08 December, 2020
Page: [959 - 968]
Pages: 10
DOI: 10.2174/2212797613666200320102503
Price: $65

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