Title:The Antihypertensive, Antimicrobial and Anticancer Peptides from <i>Arthrospira</i> with Therapeutic Potential: A Mini Review
VOLUME: 20 ISSUE: 8
Author(s):Grecia E. Barriga Montalvo, Luciana Porto de Souza Vandenberghe , Vanete Thomaz Soccol, Júlio Cesar de Carvalho and Carlos Ricardo Soccol*
Affiliation:Bioprocess Engineering and Biotechnology Department, Federal University of Paraná, Curitiba-PR, Bioprocess Engineering and Biotechnology Department, Federal University of Paraná, Curitiba-PR, Bioprocess Engineering and Biotechnology Department, Federal University of Paraná, Curitiba-PR, Bioprocess Engineering and Biotechnology Department, Federal University of Paraná, Curitiba-PR, Bioprocess Engineering and Biotechnology Department, Federal University of Paraná, Curitiba-PR
Keywords:Spirulina, bioactive peptides, antihypertensive, antimicrobial, anticancer, enzymatic hydrolysis.
Abstract:The interest in biological peptides from Arthrospira sp. (syn Spirulina) is
increasing due to its Generally Recognised as Safe “GRAS” status, the high
concentration of proteins and the history of its use as a supplement and nutraceutical
agent. Arthrospira peptides can be generated by the controlled hydrolysis of proteins,
using proteases, followed by fractionation. The peptides obtained have a range of
therapeutic effects. Amongst these bioactive peptides, three classes are of major
importance: the antihypertensive (AHP), antimicrobial (AMP) and anticancer (ACP)
peptides. AHPs have the ability to work as inhibitors of angiotensin-converting enzyme
(ACE), and help to control several diseases such as hypertension, obesity, and
cardiovascular issues, AMPs play a crucial role in the immune response, inhibiting the
development of pathogens such as bacteria, fungi, viruses and others, while ACPs can
aid in tumour control by the induction of apoptosis or necrosis, or the inhibition of
angiogenesis. Thus, bioactive peptides are of great significance to the pharmaceutical
industry. However, they can show secondary effects. This paper reviews the inhibition
mechanism of antimicrobial, hypertensive and anticancer peptides from Arthrospira sp.,
and the possible structures of the peptides according to the type of activity and its
intensity. In addition, this paper describes the purification methods of absorption
mechanisms, and reviews databases for designing peptides.
