Successful Control of a Co-Infection Caused by Candida albicans and Pseudomonas aeruginosa in Keratitis

Author(s): Debarati Paul, Suman Saha, Neelam Singh, Jayansgu Sengupta, Santi M. Mandal*

Journal Name: Infectious Disorders - Drug Targets
Formerly Current Drug Targets - Infectious Disorders

Volume 21 , Issue 2 , 2021

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Graphical Abstract:


Introduction: Nowadays, the co-infection of different classes of pathogens is a major concern. The objective of this study was to develop a successful therapy for keratitis caused by the co-infection of Candida sp. with Pseudomonas sp, which is difficult to cure. The study is based on a 47 years old male farmer showing redness and watering in the right eye for 15-days.

Methods: The microbiological examination was performed to isolate the causative organisms, i.e. Pseudomonas aeruginosa and Candida albicans. They were cultured separately along with their co-culture and treated with ciprofloxacin and amphotericin B during the growing stage to predict a definite cure.

Results: Scanning electron microscope (SEM) results confirmed the inter-specific interaction between the two different types of microorganisms. Amphotericin-B and Ciprofloxacin showed the least MIC value for both organisms in co-culture.

Conclusion: Treatment with Amphotericin-B and 5% ciprofloxacin effectively hindered the growth of Pseudomonas aeruginosa and Candida albicans, the co-infection of which caused keratitis. This therapy may be successfully implied for such cases of co-infection in the future.

Keywords: Amphotericin-B, Candida albicans, ciprofloxacin, co-infection, keratitis, Pseudomonas aeruginosa.

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Article Details

Year: 2021
Published on: 18 March, 2020
Page: [284 - 288]
Pages: 5
DOI: 10.2174/1871526520666200318111957
Price: $65

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