Background: Colorectal Cancer (CRC) is one of the most common fatal diseases with high morbidity.
Alteration of glucose metabolism is one of the hallmarks in the development of CRC. Glucose Transporter 1
(GLUT1) is a key rate-limiting protein in hyperactive glucose metabolism and up-regulated in CRC, however, the
underlying mechanism of the altered metabolism in CRC is still unknown.
Methods: In this study, immunohistochemical staining was used to evaluate the expression of GLUT1 and FOXM1 in
135 paired CRC and adjacent normal tissues. The association between the expression of GLUT1/FOXM1 and clinicopathological
factors was determined and the correlation between GLUT1 and FOXM1 in CRC was investigated.
Results: Our results revealed that regardless of tumor location, GLUT1 and FOXM1 were overexpressed in CRC
tissues, especially in patients with positive lymph node metastasis and TNM stage III-IV. Furthermore, GLUT1
showed a significantly strong link with FOXM1 in CRC tissue.
Conclusion: Overexpression of GLUT1 and FOXM1 may play critical roles in CRC leading to a poor prognosis.