Treatment of Severe Aplastic Anemia with Porcine Anti-Human Lymphocyte Globulin

Author(s): Qi Lv, Zhang Huiqin, Xiao Na, Liu Chunyan, Shao Zonghong, Wang Huaquan*

Journal Name: Current Pharmaceutical Design

Volume 26 , Issue 22 , 2020

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Abstract:

Aplastic anemia (AA) is a bone marrow failure syndrome characterized by pancytopenia. Decreased numbers of hematopoietic stem cells and impaired bone marrow microenvironment caused by abnormal immune function describe the major pathogenesis of AA. Hematopoietic stem cell transplantation and immunesuppressive therapy are the first-line treatments for AA. Porcine anti-lymphocyte globulin (p-ALG) is a new product developed in China. Several studies have shown that p-ALG exhibited good therapeutic effects in AA.

Keywords: Anemia, aplastic, porcine anti-human lymphocyte globulin, immunosuppressive, treatment, hematopoietic.

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VOLUME: 26
ISSUE: 22
Year: 2020
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DOI: 10.2174/1381612826666200317131940
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