Cytotoxic Dehydroabietylamine Derived Compounds

Author(s): Jana Wiemann, Ahmed Al-Harrasi, René Csuk*

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 20 , Issue 15 , 2020


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Graphical Abstract:


Abstract:

Background and Methods: Chemotherapy remains one of the most important methods for the treatment of cancer. More recently in this context, some products derived from natural products have raised scientific interest which especially include many terpenes. Thereby, diterpenoids represent a special class, and within this class of important secondary natural products, especially compounds derived from Dehydroabietylamine (DA), are of particular interest.

Results: This review not only gives a summary of the most important findings on the cytotoxic behavior of DAderived compounds but also shows some drawbacks of these compounds, such low bioavailability and/or poor solubility of several derivatives of DA. It focusses on the chemical aspects and summarizes the DA related biological effects without deep discussion of underlying biochemical pathways.

Conclusion: Dehydroabietylamine-derived cytotoxic compounds hold a high potential to be developed into efficient antitumor active drugs.

Keywords: Dehydroabietylamine, cancer, cytotoxicity, diterpenoids, chemotherapy, natural products.

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VOLUME: 20
ISSUE: 15
Year: 2020
Published on: 26 October, 2020
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DOI: 10.2174/1871520620666200317110010
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