Pathways Involved in Premature Ovarian Failure: A Systematic Review of Experimental Studies

Author(s): Michail Pargianas, Styliani Salta, Katerina Apostolopoulou, Leandros Lazaros, Maria Kyrgiou, Andrea Tinelli, Antonio Malvasi, Ioannis Kalogiannidis, Ioannis Georgiou, Ioannis P. Kosmas*.

Journal Name: Current Pharmaceutical Design

Volume 26 , Issue 18 , 2020

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Premature ovarian failure (POF), which may be undetectable for a long time, is associated with impaired fertility. The mechanisms involved in the pathogenesis of POF as well as the concomitant treatments are still unclear. Although many data exist, mainly produced by the study of transgenic animals under various experimental conditions, they remain fragmented. A systematic review of the pathways involved in premature ovarian failure was conducted. Data extraction was performed from experimental studies until 2019. The molecular processes and their correlation with the follicular developmental stage have been described. Furthermore, the effects in other cells, such as oocytes, granulosa and theca cells have been reported. An overall estimation was conducted.

Keywords: Fertility, folliculogenesis, ovary, POF, transgenic, follicular.

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Article Details

Year: 2020
Page: [2087 - 2095]
Pages: 9
DOI: 10.2174/1381612826666200316160145
Price: $65

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