The Influence of Vitamin D on Neurodegeneration and Neurological Disorders: A Rationale for its Physio-pathological Actions

Author(s): Maria Morello*, Massimo Pieri, Rossella Zenobi, Alessandra Talamo, Delphine Stephan, Verena Landel, François Féron, Pascal Millet

Journal Name: Current Pharmaceutical Design

Volume 26 , Issue 21 , 2020


DOI : 10.2174/1381612826666200316145725

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Abstract:

Vitamin D is a steroid hormone implicated in the regulation of neuronal integrity and many brain functions. Its influence, as a nutrient and a hormone, on the physiopathology of the most common neurodegenerative diseases is continuously emphasized by new studies. This review addresses what is currently known about the action of vitamin D on the nervous system and neurodegenerative diseases such as Multiple Sclerosis, Alzheimer’s disease, Parkinson’s disease and Amyotrophic Lateral Sclerosis. Further vitamin D research is necessary to understand how the action of this “neuroactive” steroid can help to optimize the prevention and treatment of several neurological diseases.

Keywords: Vitamin D, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis.

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