Repurposing Antihypertensive Drugs for the Management of Alzheimer’s Disease

(E-pub Ahead of Print)

Author(s): Keng Yoon Yeong*, Christine Law

Journal Name: Current Medicinal Chemistry

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Alzheimer’s disease (AD) is a neurodegenerative disorder that has affected millions of people worldwide. However, currently there is no treatment to cure the disease. The AD drugs available in the market only manage the disease symptomatically and the effects are usually short-term. Thus, there is a need to look at alternatives AD therapies. Mid-life hypertension has not only been recognised as a risk factor for AD, but its relation with AD has also been well established. Thus, antihypertensives are postulated to be beneficial in managing AD. This literature review aims to shed some light on the potential of repurposing antihypertensives to treat AD, considering recent updates. Four classes of antihypertensives, as well as their potential limitations and future prospects in being utilised as AD therapeutics are discussed in this review.

Keywords: Drug repurposing, Alzheimer's disease, anti-hypertensive, calcium channel blockers, acetylcholinesterase inhibitors, beta-blockers

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(E-pub Ahead of Print)
DOI: 10.2174/0929867327666200312114223
Price: $95

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