Background: Breast cancer (BC) accounts for one of the most prevalent malignancies in the world.
Inflammatory molecules modulate tumor microenvironment in BC that promotes tumor growth and metastasis.
NF-κB (a transcription factor) that regulates multiple immune functions and acts as a crucial mediator of inflammatory
Objective: The present study is aimed to quantitatively summarize the relation of NFKB1-94 ATTG (I, insertion/D,
deletion) variant and risk of BC.
Methods: Further, the meta-analysis includes three independent case-control investigations that focus on NFKB1-94,
ATTG I/D polymorphism, and BC patients. Web of Science, PubMed and Embase databases were used to retrieve
relevant data. OR and 95% confidence interval of pooled studies were analyzed by using the MetaGenyo web tool.
Results: This study revealed a high heterogeneity. In all three genetic comparison models, the NFKB1-94 ATTG I/D
variant is not related to the risk of BC. Further, no publication bias on the connection between NFKB1-94 ATTG I/D
variant and risk of BC was observed.
Conclusion: To summarize, our meta-analysis demonstrates that the NFKB1-94 ATTG I/D polymorphism is not a
major risk factor for BC.