Cancer Stemness as a Target for Immunotherapy is Shaped by Proinflammatory Stress

Author(s): Nese Unver*

Journal Name: Current Stem Cell Research & Therapy

Volume 16 , Issue 7 , 2021


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Abstract:

Cancer stem cells represent a rare subpopulation of cancer cells carrying self-renewal and differentiation features in multi-step tumorigenesis, tumor recurrence and metastasis. Proinflammatory stress is highly associated with cancer stemness via induction of cytokines, tumorpromoting immune cells and cancer stemness-related signaling pathways. This review summarizes the major pro-inflammatory factors affecting cancer stem cell characteristics and the critical immunotherapeutic strategies to eliminate cancer stem cells.

Keywords: Inflammation, cancer stemness, pro-inflammatory stress, cancer stem cells, pro-inflammatory cytokines, immunotherapeutic strategies.

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Article Details

VOLUME: 16
ISSUE: 7
Year: 2021
Published on: 09 March, 2020
Page: [792 - 800]
Pages: 9
DOI: 10.2174/1574888X15666200309145901
Price: $65

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