Development and Characterization of Triple Action-Dental Mold

(E-pub Ahead of Print)

Author(s): Soma Sengupta, Shounak Sarkhel, Biswajit Mukherjee*.

Journal Name: Current Dentistry

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Aim: Preparation and in vitro evaluation of polymeric molds with amoxicillin trihydrate, lidocaine hydrochloride, and metronidazole for sustained drug release for prolonged local action on an affected tooth (during carries and gum problems).

Background: Periodontal diseases with infection and inflammation cause dental pain and decay. For the treatment of dental problems such as dental pain, painkillers with antibiotics are prescribed at the initial stage. Commonly used dental liquid medications are generally washed out by saliva within a short span of application.

Objective: The main objective of the present study was to develop polymer-based dental mold containing three drugs (amoxicillin trihydrate, lidocaine hydrochloride, and metronidazole) to provide local drug action on the affected tooth or gum for a prolonged period of time.

Methods: Dental molds were prepared with drugs and a combination of polymers by mixing together in ethanol (95%) followed by solvent evaporation. The developed dental molds were evaluated using different in vitro physio-chemical methods such as tooth adhesion test, percent swelling, surface pH, scanning electron microscopy, drug content and drug-release study by simultaneous UV spectroscopy, etc.

Results: The mean adhesive strength obtained in our formulation was 46.5 g-wt with a surface pH value of 6.5. The percentage of swelling of the dental molds varied from 43% to 73% in 4 h. SEM showed very small and uniformly distributed drug particles in the matrix. Drug loading was high and reproducible. The cumulative % release of lidocaine hydrochloride, amoxicillin trihydrate and metronidazole in vitro were about 93.81%, 59.67%, 48.7%, respectively, over 24 h.

Conclusion: The developed dental mold containing three drugs may be applied to the affected tooth for prolonged drug action locally and an easy option to relieve from dental pain and infection by local drug action.

Keywords: Dental formulation, amoxicillin trihydrate, lidocaine hydrochloride, metronidazole, simultaneous equation, local action

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/2542579X02666200309124751
Price: $95