Recent studies have led to a more detailed understanding of the roles played by
microRNAs in health and disease, and their potential use as biomarkers in physiological and
pathophysiological processes involving cancer initiation and progression. MiR-492 is encoded by
a pseudogene, has a key role in some human cancer cells and its overexpression in tissues, and it
has been proposed that it can be used as a good biomarker for management and early diagnosis of
some cancers including breast cancer, colorectal and ovarian cancer, hepatocellular cancer, retinoblastoma
and pancreatic cancer. The aim of this review was to summarize the data of MiR-492
for early diagnosis and treatment of some types of related cancers.
Keywords: MiR-492, breast cancer, microRNAs, colorectal cancer, RNA-silencing, biomarker.
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