Heat shock proteins (Hsps) are a group of proteins that serve to improve cell survival
in response to a variety of environmental stresses of the host. In recent years, Hsps
gained interest in cancer therapy and as drug target against microbial infections. The antimicrobial
resistance especially by Gram-negative pathogens poses a threat to mankind. The
pathogen proteins of Hsp family yield Hsp90 inhibitor antibiotic reveal mechanisms that interact
with the ADP/ATP-sites of Hsp90. For the present review, we used the databases and
websites PubMed, SciFinder, Scopus, ProQuest, Google and Google Scholar. The review
discusses the development of Hsp90 inhibitors for bacterial as well as fungal infections and
how these inhibitors are being used for clinical trials. A systematic web search analysis was
conducted from April to November 2019.
Keywords: Hsp90, chaperone, protein, antibiotic, resistance, cancer, bacteria.
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