The Role of Ubiquitin E3 Ligase in Atherosclerosis

Author(s): Zhi-Xiang Zhou, Zhong Ren, Bin-Jie Yan, Shun-Lin Qu, Zhi-Han Tang, Dang-Heng Wei, Lu-Shan Liu, Min-Gui Fu, Zhi-Sheng Jiang*

Journal Name: Current Medicinal Chemistry

Volume 28 , Issue 1 , 2021

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Abstract:

Atherosclerosis is a chronic inflammatory vascular disease. Atherosclerotic cardiovascular disease is the main cause of death in both developed and developing countries. Many pathophysiological factors, including abnormal cholesterol metabolism, vascular inflammatory response, endothelial dysfunction and vascular smooth muscle cell proliferation and apoptosis, contribute to the development of atherosclerosis and the molecular mechanisms underlying the development of atherosclerosis are not fully understood. Ubiquitination is a multistep post-translational protein modification that participates in many important cellular processes. Emerging evidence suggests that ubiquitination plays important roles in the pathogenesis of atherosclerosis in many ways, including regulation of vascular inflammation, endothelial cell and vascular smooth muscle cell function, lipid metabolism and atherosclerotic plaque stability. This review summarizes important contributions of various E3 ligases to the development of atherosclerosis. Targeting ubiquitin E3 ligases may provide a novel strategy for the prevention of the progression of atherosclerosis.

Keywords: Atherosclerosis, ubiquitin E3 ligases, vascular inflammation, endothelial dysfunction, vascular smooth muscle cell function, lipid metabolism.

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Article Details

VOLUME: 28
ISSUE: 1
Year: 2021
Published on: 29 December, 2020
Page: [152 - 168]
Pages: 17
DOI: 10.2174/0929867327666200306124418
Price: $65

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