Discovery of Anticancer Agents from 2-Pyrazoline-Based Compounds

(E-pub Ahead of Print)

Author(s): Qing-Shan Li*, Bang-Nian Shen, Zhen Zhang, Ban-Feng Ruan, Shuying Luo.

Journal Name: Current Medicinal Chemistry

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As nitrogen-containing five-membered heterocyclic structural units, the substituted pyrazole derivatives have broad spectrum of pharmacological activities, especially 4,5-dihydro-1H-pyrazoles that also commonly known as 2-pyrazolines. Since 2010, considerable studies have been found that the 2-pyrazoline derivatives possess potent anticancer activities. In present review, it covers the pyrazoline derivatives reported by literatures from 2010 till date (2010-2019). This review aims to establish the relationship between the anticancer activities variation and different substituents introduced into 2-pyrazoline core, which could provide important pharmacophore clues for the discovery of new anticancer agents that containing 2-pyrazoline scaffold.

Keywords: 2-pyrazoline, 4 5-dihydro-1H-pyrazole, derivatives, anticancer activities, synthesis, SAR

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(E-pub Ahead of Print)
DOI: 10.2174/0929867327666200306120151
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