As nitrogen-containing five-membered heterocyclic structural units, the substituted pyrazole
derivatives have a broad spectrum of pharmacological activities, especially 4,5-dihydro-1H-pyrazoles
that also commonly known as 2-pyrazolines. Since 2010, considerable studies have been found that the
2-pyrazoline derivatives possess potent anticancer activities. In the present review, it covers the pyrazoline
derivatives reported by literature from 2010 till date (2010-2019). This review aims to establish
the relationship between the anticancer activities variation and different substituents introduced into a
2-pyrazoline core, which could provide important pharmacophore clues for the discovery of new anticancer
agents containing 2-pyrazoline scaffold.
Keywords: 2-pyrazoline, 4, 5-dihydro-1H-pyrazole, derivatives, anticancer activities, synthesis, SAR, Nitrogencontaining
heterocyclic structural units.
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