Discovery of Anticancer Agents from 2-Pyrazoline-Based Compounds

Author(s): Qing-Shan Li*, Bang-Nian Shen, Zhen Zhang, Shuying Luo*, Ban-Feng Ruan*

Journal Name: Current Medicinal Chemistry

Volume 28 , Issue 5 , 2021


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Abstract:

As nitrogen-containing five-membered heterocyclic structural units, the substituted pyrazole derivatives have a broad spectrum of pharmacological activities, especially 4,5-dihydro-1H-pyrazoles that also commonly known as 2-pyrazolines. Since 2010, considerable studies have been found that the 2-pyrazoline derivatives possess potent anticancer activities. In the present review, it covers the pyrazoline derivatives reported by literature from 2010 till date (2010-2019). This review aims to establish the relationship between the anticancer activities variation and different substituents introduced into a 2-pyrazoline core, which could provide important pharmacophore clues for the discovery of new anticancer agents containing 2-pyrazoline scaffold.

Keywords: 2-pyrazoline, 4, 5-dihydro-1H-pyrazole, derivatives, anticancer activities, synthesis, SAR, Nitrogencontaining heterocyclic structural units.

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Article Details

VOLUME: 28
ISSUE: 5
Year: 2021
Published on: 01 April, 2021
Page: [940 - 962]
Pages: 23
DOI: 10.2174/0929867327666200306120151
Price: $65

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