Background: Metoclopramide hydrochloride (MCP), a derivative of para-aminobenzoic
acid, which is a freely soluble drug, gets rapidly absorbed from the gastrointestinal tract and is used
in the management of gastrointestinal disorders such as gastric stasis, gastroesophageal reflux and
for the prevention of cancer chemotherapy induced emesis. Several brands of MCP are available in
Objective: The objective of the present study was to evaluate the quality of different marketed
products of MCP tablets 10mg, which were purchased from the retail pharmacy outlets in Abha, Riyadh
and Jeddah, Saudi Arabia with a view to determine their interchangeability in clinical practice.
Methods: The study was carried out on branded tablets by quality control tests such as weight
variation, hardness, friability, disintegration and dissolution. The results of all marketed products
complied with the official specifications.
Results: The results showed that all the parameters for MCP tablets were in accordance with the
USP limits. All the tested four brands were bioequivalent and complying with the official tests for
weight variation, friability, disintegration and dissolution tests. The percent friability was also
within the specified limit. Moreover, all formulations disintegrated within 2-6 min. The percentage
content of the active ingredient of four brands of MCP tablets showed values within the monograph
Conclusion: All the four brands evaluated in the present work could be considered bio
pharmaceutically equivalent and therefore, patients can safely switch from one brand to another
when there is the unavailability of a particular brand.