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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

Recent Advances in the Development of Broad-Spectrum Antiprotozoal Agents

Author(s): Antonio Moreno-Herrera, Sandra Cortez-Maya, Virgilio Bocanegra-Garcia, Bimal Krishna Banik and Gildardo Rivera*

Volume 28, Issue 3, 2021

Published on: 03 March, 2020

Page: [583 - 606] Pages: 24

DOI: 10.2174/0929867327666200303170000

Price: $65

Abstract

Infections caused by Trypanosoma brucei, Trypanosoma cruzi, Leishmania spp., Entamoeba histolytica, Giardia lamblia, Plasmodium spp., and Trichomonas vaginalis, are part of a large list of human parasitic diseases. Together, they cause more than 500 million infections per year. These protozoa parasites affect both low- and high-income countries and their pharmacological treatments are limited. Therefore, new and more effective drugs in preclinical development could improve overall therapy for parasitic infections even when their mechanisms of action are unknown. In this review, a number of heterocyclic compounds (diamidine, guanidine, quinoline, benzimidazole, thiazole, diazanaphthalene, and their derivatives) reported as antiprotozoal agents are discussed as options for developing new pharmacological treatments for parasitic diseases.

Keywords: Antiprotozoal, drugs, Trypanosoma brucei, Trypanosoma cruzi, Leishmania spp., Giardia lamblia, Trichomonas vaginalis, Plasmodium spp., Entamoeba histolytica.

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