Inhibitor Binding Sites in the Protein Tyrosine Phosphatase SHP-2

Author(s): Haonan Zhang, Zhengquan Gao, Chunxiao Meng*, Xiangqian Li*, Dayong Shi*

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 20 , Issue 11 , 2020

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Abstract:

Protein tyrosine phosphatase 2 (SHP-2) has long been proposed as a cancer drug target. Several small-molecule compounds with different mechanisms of SHP-2 inhibition have been reported, but none are commercially available. Pool selectivity over protein tyrosine phosphatase 1 (SHP-1) and a lack of cellular activity have hindered the development of selective SHP-2 inhibitors. In this review, we describe the binding modes of existing inhibitors and SHP-2 binding sites, summarize the characteristics of the sites involved in selectivity, and identify the suitable groups for interaction with the binding sites.

Keywords: PTP, SHP-2, SHP-1, protein tyrosine kinases, PTKs, cancer.

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VOLUME: 20
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Year: 2020
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